Developing Translational PD Biomarkers in Idiopathic Pulmonary Fibrosis

Time: 11:30 am
day: Day Two Morning


• The generation of translational pharmacology data packages using systems and biomarkers that can be linked to the clinical setting is pivotal for successful drug development
• This is especially challenging in the field of fibrosis where models have questionable translatability and there are limited approved therapies for pre-clinical benchmarking, however, with appreciation of the limitations of pre-clinical models and an understanding of the key questions it is possible to map a path to the clinic
• Example cases studies will be presented focussing on small molecule therapies targeting integrins and lectins for idiopathic pulmonary fibrosis highlighting the opportunities and challenges encountered during biomarker development