Patient-First Drug Discovery Using Primary Patient Tissues and AI
Time: 1:40 pm
day: Track A - Day 2 am
- The use of primary tissues from cancer patients in translational research provides disease-relevant model systems
- High-content microscopy, transcriptomics, and AI are powerful tools to enable single-cell interrogation of drug and target function within diseased tissue, harnessing potential inter-patient response heterogeneity for preclinical biomarker prediction.
- Our methodology for assessing functional drug response has been clinically validated through the prospective clinical study EXALT-I prioritising therapy for late-stage haematological cancer patients.