Job title: Senior Scientist, Biomarker Lead
Within the New Therapeutics Target Discovery team from the R&D department at uniQure, Astrid is leading the early stage biomarker development activities. As a molecular neurobiologist, Astrid has a broad interest in the molecular basis of brain functioning in health and disease. Her previous work in both academic and pharma settings included activities in target discovery, preclinical disease modeling and molecular mechanisms of disease, in relation to neuroendocrinology, neuroimmunology, neuroplasticity and neurodevelopmental disorders. Since joining uniQure at the end of 2016, Astrid has shaped the translational activities of uniQure’s Huntington Disease (HD) gene therapy program, with focus on building the rationale for biomarker panel selection, exploring novel bioanalytical methods, and performing preclinical work in small and large animal models to evaluate biofluid and imaging candidate efficacy measures. With uniQure’s HD program now entering the clinic, she continues to support the clinical team in the core activities related to HD biomarkers for the ongoing phase I/IIa trial.